Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene - SpringerBriefs in Applied Sciences and Technology - Amita Kashyap - Livros - Springer Verlag, Singapore - 9789814585071 - 22 de setembro de 2014
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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene - SpringerBriefs in Applied Sciences and Technology 2015 edition

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Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10?30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies.

This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.


79 pages, 1 black & white illustrations, 39 colour illustrations, biography

Mídia Livros     Paperback Book   (Livro de capa flexível e brochura)
Lançado 22 de setembro de 2014
ISBN13 9789814585071
Editoras Springer Verlag, Singapore
Páginas 72
Dimensões 155 × 235 × 4 mm   ·   127 g
Idioma Inglês  

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