Debating Cancer: the Paradox in Cancer Research - Heng, Henry H (Wayne State University School of Medicine, USA) - Livros - World Scientific Publishing Co Pte Ltd - 9789814520843 - 3 de dezembro de 2015
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Heng, Henry H (Wayne State University School of Medicine, USA)
Debating Cancer: the Paradox in Cancer Research

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Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts and accumulated knowledge on cancer genes and pathways, the clinical benefits of this traditional approach have been limited. Recently, cancer genome sequencing has revealed an extensive amount of genetic heterogeneity where the long expected common mutation drivers have been difficult, if not impossible, to identify. These realities ultimately challenge the conceptual framework of current cancer biology. This book introduces a new concept of genome theory of cancer evolution to unify the field. Many important and representative, but often confusing, questions and paradoxes will be critically analyzed. By comparing gene and genome-based theories, the hidden flaws of many popular viewpoints are addressed. This discussion is intended to initiate a much-needed critical re-evaluation of current cancer research.

400 pages

Mídia Livros     Hardcover Book   (Livro com lombada e capa dura)
Lançado 3 de dezembro de 2015
ISBN13 9789814520843
Editoras World Scientific Publishing Co Pte Ltd
Páginas 464
Dimensões 236 × 164 × 30 mm   ·   796 g
Idioma Inglês  

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